GATTEX was clinically proven to reduce volume of and time on PS; for some adults, GATTEX resulted in complete freedom from PS.

MOST ADULTS ACHIEVED LESS VOLUME OF PS WITH GATTEX

At 6 months, 63% on GATTEX vs. 30% on placebo reduced weekly parenteral support

of adults reduced their PS volume
by 20% or more

At 30 months, 93% of adults on GATTEX saw a 7.55-liter average weekly reduction in PS volume

of adults reduced their PS volume by 20% or more

MOST ADULTS ACHIEVED MORE TIME OFF PS WITH GATTEX

At 6 months, 54% of adults on GATTEX vs. 23% on placebo had at least 1 day off parenteral support

of adults achieved
1 or more days off PS per week

At 30 months, 60% of adults on GATTEX had 3 or more days off parenteral support per week

of adults achieved
3 or more days off PS per week

Marrika, a GATTEX patient living with SBS, reflects on her experience with treatment

After starting GATTEX, I was able to reduce my PS volume and time from 7 days to 5 days. This time off PS gave me freedom to do more activities with my family.”

MARRIKA, TREATING HER SBS WITH GATTEX. INDIVIDUAL RESULTS MAY VARY.

FREEDOM FROM PS MAY BE POSSIBLE

At 30 months with GATTEX

10 out of 30 people

no longer needed PS*

Achieving complete freedom from parenteral support (PS) took about 7 to 30 months, with the average at approximately 20 months.

Not everyone who takes GATTEX will fully wean off of PS.

* In STEPS-2, participants were maintained on GATTEX even if they no longer required PS.

Over time with GATTEX, my doctors started slowly reducing my weekly PS volume. A year later, my PS had been stopped altogether.

BETSY, TREATING HER SBS WITH GATTEX. INDIVIDUAL RESULTS MAY VARY.

How long does it take to see results while taking GATTEX?

The time it takes to reduce weekly PS volume can vary. In adult clinical studies, some people experienced improved results the longer they stayed on GATTEX.

How long it took to reduce weekly PS volume by at least 20%:

Picture, Picture
~1 month

Some adults were able to reduce their weekly PS volume after about 1 month of treatment with GATTEX

≥12 months

Others being treated with GATTEX took 12 months or longer. Some people did not respond at all.

43 patients in STEPS study received GATTEX.

How long it took to achieve freedom from PS:

Picture
~7 months

Some people were able to fully wean off of PS after 7 months of treatment with GATTEX

~30 months

Some people needed up to 30 months of treatment with GATTEX to fully wean off of PS.

88 people in STEPS-2 study received GATTEX, including 30 who received GATTEX for 30 months. Not everyone who takes GATTEX will fully wean off of PS. No one receiving GATTEX during the 6-month STEPS study achieved PS independence.

After starting treatment with GATTEX, I was able to eventually wean completely off PS. I like having my freedom from PS.

DENISE, TREATING HER SBS WITH GATTEX. INDIVIDUAL RESULTS MAY VARY.

In a 6-month study, 27 out of 43 adults treated with GATTEX reduced weekly PS volume by 20% or more versus 13 out of 43 on placebo. In a 24-month extension study, 10 out of 30 adults previously on GATTEX no longer needed PS after 30 months of treatment.