Watch a video about the science behind GATTEX and explore the GATTEX study details.

GATTEX® (teduglutide [rDNA origin]) for Injection is a prescription medicine used in adults with Short Bowel Syndrome (SBS) who need additional nutrition or fluids from intravenous (IV) feeding (parenteral support).

How GATTEX® works

“My surgeon had heard about GATTEX, and he explained the science of it to me.”

Lynda is a real patient taking GATTEX.

See the science behind GATTEX.

What is GLP-2?

When people eat, the lower part of the intestine produces a hormone called glucagon-like peptide-2 (GLP-2). GLP-2 helps the intestine absorb nutrients and fluids from food and drink. Usually, people with Short Bowel Syndrome (SBS) have undergone surgery to remove a large portion of the intestine, including the part that produces GLP-2. For SBS patients, the amount of nutrients and fluids the remaining intestine is able to absorb can be limited because so much intestine has been removed along with this important hormone.

Naturally occurring GLP-2 amino acid sequence

How naturally occurring GLP-2 works

GATTEX mimics GLP-2

GATTEX is the first and only medicine that mimics naturally occurring GLP-2 and it may help the intestine that is left absorb more fluids.

GATTEX amino acid sequence

How GATTEX works

GATTEX is proven to help the remaining bowel absorb more

A study showed that GATTEX increased the surface area in the remaining bowel and enhanced fluid absorption for people with SBS.

Explore the study details

The ability of GATTEX to improve the amount of fluids absorbed by the intestines was studied in 17 adults with SBS. People in the study received GATTEX for 21 days. They each took daily doses of either 0.03, 0.10, 0.15 mg/kg via injections administered under the skin into the stomach area (abdomen). All the people in this study knew they were taking GATTEX.

All of the doses studied, except for the 0.03 mg/kg once-daily dose, resulted in enhanced absorption of fluid by the intestines — approximately 750 to 1000 mL per day — and increased the surface area of the intestines.*

*The recommended once-daily dose of GATTEX is 0.05 mg/kg. Doctors should reduce the dose by 50% in patients with moderate and severe renal impairment (creatinine clearance <50 mL/min) and end-stage renal disease. Please see the full Prescribing Information for Dosage and Administration.

Enhanced gastrointestinal fluid absorption by approximately 750 to 1000 mL per day

It’s important to work closely with your doctor when taking GATTEX

GATTEX may cause serious side effects, including fluid overload.

Fluid overload and heart failure were reported in patients taking GATTEX in clinical studies. Too much fluid in your body may lead to heart failure, especially if you have heart problems. Your healthcare provider will check you for too much fluid in your body. Tell your healthcare provider if you get swelling in your feet and ankles, you gain weight very quickly (water weight), or you have trouble breathing.

Keep Learning About GATTEX Callout

Keep learning about GATTEX

GATTEX was studied in adults with SBS who needed additional nutrition or hydration from IV feeding, also known as parenteral support.

See the results

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Important Safety Information: GATTEX may cause serious side effects including making abnormal cells grow faster, polyps in the colon (large intestine), blockage of the bowel (intestines), swelling (inflammation) or blockage of your gallbladder or pancreas, and fluid overload.
Click here for additional Important Safety Information.