GATTEX MAY BE A POSSIBILITY FOR YOU

“My surgeon told me about the risks and benefits of a prescription drug called GATTEX.”

—Misa, Gattex Patient

GATTEX is a prescription medicine for adults with short bowel syndrome (SBS) who need additional nutrition or fluids from intravenous (IV) feeding, also known as parenteral support (PS).

GATTEX was studied in a 6-month clinical trial of 86 adult SBS patients who needed to use PS at least 3 times a week for at least 1 year. 63% of patients receiving GATTEX reduced weekly PS volume by 20% or more vs 30% of people receiving placebo. 54% of patients receiving GATTEX achieved at least 1 day off PS vs 23% of people receiving placebo.


The best way to find out if GATTEX is right for you is to talk with your doctor.


How GATTEX works

To understand how GATTEX works, it’s best to begin with GLP-2.

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What is GLP-2?

When people eat, the lower part of the intestine produces a hormone called glucagon-like peptide-2 (GLP-2). GLP-2 helps the intestine absorb nutrients and fluids from food and drink.

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Patients with SBS may not have enough GLP-2

Usually, people with short bowel syndrome have undergone surgery to remove a large amount of the intestine. This includes portions that may produce GLP-2. That limits the amount of nutrients and fluids the remaining intestine is able to absorb.

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GATTEX works like natural GLP-2

GATTEX is the first and only medicine that works like the GLP-2 your body normally makes on its own. It may help the intestine that is left absorb more fluids.


GATTEX is proven to help the remaining bowel absorb fluid in adults with SBS.

A study showed that GATTEX increased the surface area in the remaining bowel and enhanced fluid absorption for people with SBS. See below for more details.


Explore the study details

The ability of GATTEX to improve the amount of fluids absorbed by the intestines was studied in 17 adults with SBS.


People in the study received GATTEX for 21 days.


They each took daily doses of either 0.03, 0.10, or 0.15 mg/kg by injection. The injections were administered under the skin into the stomach area (abdomen).


All the people in this study knew they were taking GATTEX.


All of the doses studied, except for the 0.03 mg/kg once-daily dose, resulted in enhanced absorption of fluid by the intestines—approximately 750 to 1000 mL per day—and increased the surface area of the intestines.*


*The recommended dosage in patients with moderate and severe renal impairment and end-stage renal disease (creatinine clearance <60 mL/min) is 0.025 mg/kg once daily.

See how GATTEX worked for adults with SBS in studies.

What is GATTEX?

Important Safety Information

GATTEX may cause serious side effects including making abnormal cells grow faster, polyps in the colon (large intestine), blockage of the bowel (intestines), swelling (inflammation) or blockage of your gallbladder or pancreas, and fluid overload. Click here for additional Important Safety Information.

GATTEX® (teduglutide) for subcutaneous injection is a prescription medicine used in adults with Short Bowel Syndrome (SBS) who need additional nutrition or fluids from intravenous (IV) feeding (parenteral support).

Click here for additional Important Safety Information.

What is GATTEX?

GATTEX® (teduglutide) for subcutaneous injection is a prescription medicine used in adults with Short Bowel Syndrome (SBS) who need additional nutrition or fluids from intravenous (IV) feeding (parenteral support).

Important Safety Information

What is the most important information I should know about GATTEX?

GATTEX may cause serious side effects, including:

Making abnormal cells grow faster

GATTEX can make abnormal cells that are already in your body grow faster. There is an increased risk that abnormal cells could become cancer. If you get cancer of the bowel (intestines), liver, gallbladder or pancreas while using GATTEX, your healthcare provider should stop GATTEX. If you get other types of cancers, you and your healthcare provider should discuss the risks and benefits of using GATTEX.

Polyps in the colon (large intestine)

Polyps are growths on the inside of the colon. Your healthcare provider will have your colon checked for polyps within 6 months before starting GATTEX and have any polyps removed.

To keep using GATTEX, your healthcare provider should have your colon checked for new polyps at the end of 1 year of using GATTEX. If no polyp is found, your healthcare provider should check you for polyps as needed and at least every 5 years and have any new polyps removed. If cancer is found in a polyp, your healthcare provider should stop GATTEX.

Blockage of the bowel (intestines)

A bowel blockage keeps food, fluids, and gas from moving through the bowels in the normal way. Tell your healthcare provider right away if you have any of these symptoms of a bowel or stomal blockage:

If a blockage is found, your healthcare provider may temporarily stop GATTEX.

Swelling (inflammation) or blockage of your gallbladder or pancreas

Your healthcare provider will do tests to check your gallbladder and pancreas within 6 months before starting GATTEX and at least every 6 months while you are using GATTEX. Tell your healthcare provider right away if you get:

Fluid overload

Your healthcare provider will check you for too much fluid in your body. Too much fluid in your body may lead to heart failure, especially if you have heart problems. Tell your healthcare provider if you get swelling in your feet and ankles, you gain weight very quickly (water weight), or you have trouble breathing.

The most common side effects of GATTEX include:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

What should I tell my healthcare provider before using GATTEX?

Tell your healthcare provider about all your medical conditions, including if you:

Tell your healthcare providers about all the medicines you take, including prescription or over-the-counter medicines, vitamins, and herbal supplements. Using GATTEX with certain other medicines may affect each other causing side effects. Your other healthcare providers may need to change the dose of any oral medicines (medicines taken by mouth) you take while using GATTEX. Tell the healthcare provider who gives you GATTEX if you will be taking a new oral medicine.

Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

For additional safety information, click here for full Prescribing Information.